Yes, but be mindful that the cooler is powered by your car's battery. Run it too long, and the car's battery might drain completely. Luckily, many electric coolers produce a "low voltage" alert ...

The Glacier can be powered through an AC outlet, a 12V car outlet or an optional 298 Wh battery, which neatly stows inside the cooler’s housing. EcoFlow claims its battery will power the cooler ...