Hyponatremia commonly occurs in patients with aneurysmal subarachnoid hemorrhage. Two mechanisms have been proposed as causes: syndrome of inappropriate anti-diuretic hormone and cerebral salt ...
2008;6(5):601-608. The first Phase III clinical trial to study tolvaptan was the Study of Ascending Levels of Tolvaptan in Hyponatremia (SALT)-1/-2, which consisted of two identical efficacy trials.