Currently, it is difficult to predict the way in which mtDNA mutations will pass from mother to child due to the interplay between the mitochondrial and nuclear genomes. It is clear, however ...

METTL4 (methyltransferase-like protein 4) mediates N6- methyldeoxyadenosine (6mA) of mammalian mitochondrial DNA (mtDNA). However, the role of METTL4-mediated mitoepigenetic regulation in ...

There are 11 nucleotide positions at which the original sequence contains the incorrect nucleotide (all sequences here refer to that of the CRS mtDNA L-strand), one of which involves the CC ...

suspects of crimes and in paternity testing. It's also the one used to identify the remains of victims of the September 11th attacks. The other approach analyzes mitochondrial DNA, or mtDNA.

sergas.es Objectives To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance ...

It uses a binomial mixture model to assess the heteroplasmy of mtDNA variants among background noise. For droplet-based sequencing data, eg. 10X Chromium CNV, scATAC..etc, it is recommended to add ...

Defects in the mitochondrial respiratory chain and a substantial decrease in mtDNA levels were found in ... the study opens new possibilities for genetic testing and treatment development.

Patients and methods: The examination of index patients included a detailed clinical characterisation, histological analysis of muscle biopsy specimens, and genetic testing of mitochondrial ... yet ...