Lockard’s 1-year-old daughter Naomi had just been diagnosed with hereditary spastic paraplegia-50, or SPG50, a condition known to affect around 100 people on the planet.

We describe a family with pure X-linked hereditary spastic paraplegia (HSP) and report linkage to X-chromosome DNA probes. A 6-generation pedigree (K313) with 12 affected males is presented.

Hereditary spastic paraplegia, or HSP, is a group of movement disorders that cause progressive weakness and stiffness in the ...

In particular we are investigating the involvement of axonal transport in diseases including motor neurone disease (MND) and hereditary spastic paraplegia (HSP). In addition we are developing and ...

Jack lives with a rare disease called hereditary spastic paraplegia type four (SPG4). Thanks to a generous gift, they not only wound up with tickets to the first concert, but also managed to raise ...